Wanying Ma

The Nuclear Targeted Type‑I Photosensitizer for Anti-Tumor Therapy Photodynamic therapy (PDT) has attracted considerable interest in recent years as an effective and promising approach for tumor treatment. In particular, the nuclear-targeted type I photosensitizers (PSs) can directly damage nuclear DNA of tumor cells, thereby significantly enhancing the therapeutic efficacy of PDT. However, the nuclear DNA-targeted PSs are rarely reported owing to the lack of clear design principles.

Abstract In vaccine clinical trials, vaccine efficacy endpoint analysis is usually associated with in high cost or extended study duration, due to the generally low infection rate. Correlate of protection (CoP), which refers to surrogate endpoint, usually immunological response, that can reliably predict the treatment effect, provides a more efficient and less costly approach to evaluate the vaccine.