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General anesthesia vs. non-general anesthesia for elderly stroke patients treated with mechanical thrombectomy
Abstract Objective: This study aimed to compare the impact of general anesthesia (GA) versus non-GA on functional outcomes in elderly patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke. Methods: A total of 707 elderly stroke patients (mean age 74.7 ± 6.8 years; 57.0% male) who received EVT were retrospectively analyzed. Patients were stratified into GA (48.1%) and non-GA (51.9%) groups.
Glial Fibrillary Acidic Protein Levels
Introduction Stroke is estimated to be the leading cause of acquired disability and mortality worldwide.1 Post-stroke depression (PSD) is a common complication that affects approximately one-third of ischemic stroke survivors.2–4 PSD may negatively affect the quality of life after ischemic stroke, and impair recovery of cognitive and motor function.5,6 Also, a meta-analysis included 15 prospective cohort studies with 250,294 participants suggesting that PSD is significantly correlated with an...
Melatonin Provides Protection Against Cisplatin-Induced Ovarian Damage and Loss of Fertility in Mice
Abstract Research question Whether melatonin can provide non-invasive ovarian protection against damage caused by cis-diamminedichloroplatinum (cisplatin) and preserve fertility for female cancer patients? And what is the possible mechanism if it is the case? Design Athymic BALB/c-nu nude tumor-bearing female mice were employed to exclude the antagonistic effect towards cisplatin-based anticancer therapy and promoting cancer effect of melatonin.
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