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IL-15 and its receptor ? (IL-15R?) are co-expressed on antigen-presenting cells, allowing transpresentation of IL-15 to immune cells bearing IL-2R?? and stimulation of effector immune responses. We reported previously that the high-affinity interactions between an IL-15 superagonist (IL-15N72D) and the extracellular IL-15R? sushi domain (IL-15R?Su) could be exploited to create a functional scaffold for the design of multivalent disease-targeted complexes.
Interleukin (IL)-15 and its receptor α (IL-15Rα) are co-expressed on antigen-presenting cells allowing transpresentation of IL-15 to immune cells bearing IL-2RβγC and stimulation of effector immune responses. We previously reported that the high-affinity interactions between an IL-15 superagonist (IL-15N72D) and the extracellular IL-15Rα sushi domain (IL-15RαSu) could be exploited to create a functional scaffold for the design of multivalent disease-targeted complexes.
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