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Articles by Warwick Engineering

Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects

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By James Everett, Warwick Engineering, Joanna F. Collingwood, Vindy Tjendana-Tjhin
| Royal Society of Chemistry Verified
Altered metabolism of biometals in the brain is a key feature of Alzheimer's disease, and biometal interactions with amyloid-β are linked to amyloid plaque formation. Iron-rich aggregates, including evidence for the mixed-valence iron oxide magnetite, are associated with amyloid plaques.
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Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease

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By James Everett, Neil D. Telling, Joanna F. Collingwood, Warwick Engineering
| Cell Press Verified
Analysis of Morphology and Oxidation State of Iron   In Situ Combined Nanoscale Measurements of Iron Oxidation and Magnetism On adjacent semi-thin sections taken from the same transgenic sample we found particulate iron deposits that showed a strong spatial variation in iron oxidation state over regions as small as ?50 nm, an example of which is shown in Figure 5Figure 5. Iron L X-ray absorption spectra taken from representative regions in the deposit are shown in Figure 5Figure 5F.
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