Wassila Rahali on Muck Rack

Wassila Rahali

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Articles

CAR T cell-mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis

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By Fangyuan Gao, Ziyuan He, Lan Ma, Myriam Ben Khelil, Jessica Rengassamy, Roula Amine-Hneineh, Rémy Jelin, Wassila Rahali, Paul-Auguste Goutebroze
| Science Magazine Verified
Editor’s summary Hematotoxicity is a complication of CAR T cell therapy in which patients who receive CAR T cells have a decrease in the cells of the bone marrow and blood or cytopenia, which negatively influences patient outcomes. Ben Khelil et al. used a mouse B cell lymphoma model to investigate the mechanisms underlying hematotoxicity after CAR T cell therapy and found that CAR T cells were required for hematotoxocity.
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