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Articles by Wayne Hellstrom
Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies
Statistical analyses Based on FDA guidelines for studies on testicular toxicity,9 it was agreed that a pooled sample size of 200 patients (100 patients per treatment group) across both studies would be adequate for providing cumulative distribution curves and an estimate with a reasonably narrow 95% CI for the primary endpoint.
Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies
AEs and changes in laboratory parameters and vital signs Cumulative safety data were examined through the cut-off date. In MANTA, the mean (SD) exposure to DB or OL filgotinib among the 69 patients who were originally assigned to DB filgotinib was 73.1 (35.3) weeks. The mean (SD) exposure to DB placebo was 48.9 (38.2) weeks for the 70 patients who were originally assigned to DB placebo.
Testosterone Assays
McEwan I.J. Brinkmann A.O. Androgen Physiology: Receptor and Metabolic Disorders. 2021 Jul 2. in: Feingold K.R. Anawalt B. Boyce A. Endotext [Internet]. MDText.com, Inc., South Dartmouth (MA)2000 () Guideline of guidelines: testosterone therapy for testosterone deficiency. BJU Int. 2019; 124: 722-729 Mulhall J.P. Trost L.W. Brannigan R.E. et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018; 200: 423 Vermeulen A. Verdonck L.
Revelations on Men Who Seek Penile Augmentation Surgery: A Review
Abstract Introduction Men with normal penis size sometimes mistakenly believe they have below average penile dimensions and often seek out treatment. Many men suffer from significant anxiety regarding this perceived defect. In this review, we evaluate the current literature of psychological, medical, and surgical treatment options for men with a complaint of a small penis. Objective To review the current practice for treatment of men presenting for penile augmentation surgery.
Testosterone therapy may be safe for use in men with advanced prostate cancer
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Re: Testosterone Therapy in Men with Biochemical Recurrence and Metastatic Prostate Cancer: Initial Observations
Testosterone replacement therapy (TRT) has been a topic of controversy since its beginnings almost 90 years ago.1 Initially employed to reverse age-related ailments and as a fountain-of-youth treatment, there was a pendulum shift with the Huggins and Hodges proposal that testosterone activates prostate cancer growth.2 In 1981, Fowler and Whitmore reported that 45 of 52 men with metastatic prostate cancer (MET) who received testosterone demonstrated an unfavorable response within 30 days.3 The...
Re: Effect of Natesto on Reproductive Hormones, Semen Parameters and Hypogonadal Symptoms: A Single Center, Open Label, Single Arm Trial
Wayne J.G. Hellstrom Wayne J.G. Hellstrom Correspondence Corresponding author. Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA. Affiliations Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA Search for articles by this author Ayman Soubra
Updated Review of Testosterone Replacement Therapy in the Setting of Prostate Cancer
Introduction Prostate cancer (PCa) is the most common cancer in men in the United States, with ∼192,000 new cases in 2020.1 This number of annual cases is expected to rise as the population ages. For patients deemed to have low-risk PCa, active surveillance (AS) is an accepted treatment option.2–5 In cases that require treatment, surgery, radiation therapy, high-intensity focused ultrasound (HIFU), and cryotherapy are available options.
Clomiphene Citrate for Male Hypogonadism and Infertility: An Updated Review
Introduction The prevalence of male hypogonadism is estimated to be between 2% and 13% of the adult male population in the world.1 Incidence rises with age, with up to 40% of men aged ≥45 years diagnosed with hypogonadism through various testosterone assays.2 In middle-aged men, total testosterone is approximated to have a 0.8–1.6% yearly decline.3 Decreased libido, depressed mood, lack of energy, diminished mental concentration, erectile dysfunction, and decreased muscle mass are common...
Does Lowering Hemoglobin A1c Reduce Penile Prosthesis Infection: A Systematic Review
Abstract Introduction Hemoglobin A1c (HbA1c), a glycated form of hemoglobin, develops when glucose is elevated in the blood. It is used as a marker of how well a diabetic patient has been controlling their blood sugar over the previous 3–4 months. Some use HbA1c as a predictor of infection risk during prosthetic surgery, and many surgeons require patients to lower it preoperatively. Objective This study was designed to comprehensively review the literature relating HbA1c and penile prosthesis (PP).
Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature
After removing duplicates, a total of 407 studies were identified by the literature search and independently screened. Of these articles, 52 fit the inclusion criteria and were further assessed for eligibility (Fig. 1Fig. 1): 17 comparative studies [6x[6]Gelbard, M., Goldstein, I., Hellstrom, W.J.G. et al. Clinical efficacy, safety and tolerability of collagenase Clostridium histolyticum for the treatment of Peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies.
Post-Orgasmic Illness Syndrome: A Review
Publication HistoryPublished online: November 08, 2017Accepted: August 26, 2017; Received: June 1, 2017;
Re: Multicenter Investigation of the Micro-organisms Involved in Penile Prosthesis Infection: An Analysis of the Efficacy of the AUA and EAU Guidelines for Penile Prosthesis Prophylaxis - European Urology
Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017
Editorial: Semen Proteome Alterations in the Smoking Male
Infertility affects 15% of couples, with male factor infertility influencing half of such couples [1]. Multiple environmental risk factors for male infertility have been identified, including: diet, exposure to pollution, and multiple substance abuses, e.g. alcohol, tobacco, marijuana, opiates [2]. In this issue of BJUI, the study of Antoniassi et al. [3] makes an important contribution to the literature regarding the impact of a particular environmental factor, smoking, on male factor infertility.
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