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Articles by Wayne Lee
Publisher Correction: CFTR mediates Cl - transport in osteocytes to sustain cell viability and skeletal homeostasis
Correction to: Nature Communications https://doi.org/10.1038/s41467-026-72349-0, published online 28 April 2026 In Fig. 2e of this article, the Exon 4_KO sequence was inadvertently omitted by the Publisher; the original and corrected figure panel is shown below. The original article has been updated. Incorrected Fig. 2e Corrected Fig.
Artificial intelligence for scoliosis surgical planning and postoperative prediction
Abstract Adolescent idiopathic scoliosis (AIS) surgery requires precise fusion segment selection and reliable prediction of postoperative alignment, yet current tools lack individualized, validated solutions. We developed ScoliosisPLAN, an AI-based system integrating a YOLOv8-derived segmentation model (ScolioPlanNet) for personalized fusion planning and a latent diffusion model (ScolioPredNet) for simulating postoperative radiographs.
CFTR mediates Cl - transport in osteocytes to sustain cell viability and skeletal homeostasis
Abstract Osteocytes are long-lived with underlying mechanisms largely unknown. Here, we report that osteocyte-specific knockout of cystic fibrosis transmembrane conductance regulator (CFTR) results in excessive osteocyte death, proinflammatory cytokine surge, osteoclast overactivation and bone formation impairment leading to bone loss in adult mice. Consistently in MLO‑Y4 osteocyte‑line, CFTR-knockout causes progressive cell death, which is reversed by CFTR overexpression or medium replenishment.
The need for more parking
The San Francisco Peninsula, stretching from the vibrant city of San Francisco down to the suburban heartlands of Silicon Valley, is home to a diverse array of business districts. From bustling downtowns to tech hubs and charming commercial centers, this region is a key economic driver for the Bay Area. However, one challenge that has increasingly hindered the growth and sustainability of these business districts is the pervasive issue of inadequate parking.
Arena studies are ‘window dressing’ to obscure who the main beneficiaries of 76 Place will be | Opinion
The city released impact studies for the proposed 76ers arena in Center City last week. Among the hundreds of pages and projections of the reports — which were funded by the Sixers — one essential truth is clear: Chinatown will not benefit if 76 Place gets the green light. It might not even survive. These studies are window dressing to obscure the fact that the main beneficiaries of this project will be the billionaires who proposed it.
Incorporating AI into cardiovascular diseases prevention-insights from Singapore
Summary Improved upstream primary prevention of cardiovascular disease (CVD) would enable more individuals to lead lives free of CVD. However, there remain limitations in the current provision of CVD primary prevention, where artificial intelligence (AI) may help to fill the gaps.
New Zardoor backdoor used in long-term cyber espionage operation targeting Islamic organization
By Jungsoo An, Wayne Lee and Vanja Svajcer. Cisco Talos discovered a new, stealthy espionage campaign that has likely persisted since at least March 2021.
Victims of Deadly New York City Fire to Be Memorialized Sunday
Plans are underway for a large communal memorial service Sunday for victims of New York City's deadliest fire in more than three decades. Seventeen people, including eight children, were killed when a fire broke out on January 9 at a high rise residential building in the working class Fordham Heights neighborhood in the Bronx, a New York borough with a large African and Latino community.
US Hiring Slows in December
WASHINGTON — U.S. employers added 199,000 new jobs in December, 50,000 fewer than November, the Labor Department reported Friday, as business continue to struggle to fill vacancies due to American workers' reluctance to return to the workforce during the ongoing coronavirus pandemic. Despite the hiring slowdown, December's jobless rate fell to a healthy 3.9% — a 22-month low — from November's 4.2%.
US Expands Booster Shot Eligibility for Teens; Strengthens Recommendations to Fight Omicron Variant
The U.S. Centers for Disease Control and Prevention expanded COVID-19 booster shot eligibility for some adolescents to combat the highly transmissible omicron variant of the coronavirus. The move comes as the agency faces criticism over confusing messaging on how to cope with infections. In a statement late Wednesday, CDC Director Rochelle Walensky urged youngsters age 12 and older to get a COVID-19 booster as soon as they're eligible.
White House Ramps Up Anti-COVID Efforts as Omicron Threatens to Swamp Hospitals
U.S. President Joe Biden’s administration is ramping up its national coronavirus containment campaign as record-high infections fueled by the omicron variant threaten to overwhelm hospitals and disrupt some school reopening plans. The United States reported one million new infections on Monday, the highest of any country in the world.
US November Job Gains Fall Short of Expectations
WASHINGTON — U.S. employers added only 210,000 jobs in November, the Labor Department reported Friday, dampening hopes the economy is rebounding from a summer slowdown sparked by the highly contagious delta variant of the coronavirus and supply chain disruptions. Millions of Americans laid off during the pandemic-induced recession remained without work last month despite employers offering higher wages, expiring unemployment benefits and schools reopening.
Juneteenth Becomes US Federal Holiday
WASHINGTON - Juneteenth is America’s newest federal holiday after President Joe Biden signed it into law Thursday. But African Americans have celebrated every June 19 since 1865, when the last enslaved Blacks learned of their freedom on that date, two-and-a- half years after President Abraham Lincoln signed the Emancipation Proclamation. It also has been a day to reflect on their struggle for freedom and justice, and to teach vital history to younger generations.
Beyond the Machine: Game Changers in the Floor Sanding World
Shutterstock © The phrase “game-changer” is being used more and more during these past few years. It seems like the task of sanding floors has become a huge work of art, rather than just getting them flat and smooth. I commonly am asked what are the biggest improvements to the sanding market, and how did the “older” floor companies get the floors sanded as flat as we do today? In speaking with some of the more-experienced floor sanders, the responses have quite a wide range.
We must end all anti-Asian violence
In March 2020, soon after Bay Area governments ordered pandemic-related lockdowns, a non-Asian woman gave up her spot in line outside the Millbrae Trader Joe’s to cough at then-Millbrae Councilman Wayne Lee, as he walked past. Three months later, an unknown person(s) threw a brick through a window at the home of San Mateo Councilwoman Amourence Lee. Wayne and Amourence are unrelated.
Jesuits in US Pledge $100 Million for Racial Reconciliation
The U.S.-based branch of the Jesuits has unveiled ambitious plans for a "truth and reconciliation" initiative in partnership with descendants of people once enslaved by the Roman Catholic order. The Jesuits pledge to raise $100 million within five years with a broader goal of reaching $1 billion from an array of donors in pursuit of racial justice and racial healing.
Peace Corps Marks 60 Years of Global Volunteerism
The U.S. Peace Corps turns 60 Monday. Since its establishment through executive order by President John F. Kennedy on March 1, 1961, the Peace Corps has sent more than 240,000 volunteers to 141 countries. The organization quickly became an icon of the idealistic 1960s.
US Peace Corps Marks 60 Years of Global Volunteerism
The U.S. Peace Corps turns 60 Monday. Since its establishment through executive order by President John F. Kennedy on March 1, 1961, the Peace Corps has sent more than 240,000 volunteers to 141 countries. The organization quickly became an icon of the idealistic 1960s.
Mexican President Calls for UN Intervention on Global Vaccine Rollout
Mexican President Andrés Manuel López Obrador called on the United Nations on Tuesday to guarantee equitable access to coronavirus vaccines. Speaking at a news conference alongside Argentine President Alberto Fernández, Lopez Obrador called the current state of vaccine distribution "totally unfair." "The U.N. has to intervene because it's ... an ornament," he said.
Khamenei Says Iran Could Enrich Uranium to 60%
Iran's Supreme Leader Ayatollah Ali Khamenei said on Monday Iran could increase its level of uranium enrichment to whatever the country needs, including up to 60%, as a standoff between Iran and the United States continues over the future of the Iran nuclear deal. State television quoted Khamenei on Monday as saying, "Americans and the European parties to the deal have used unjust language against Iran. ... Iran will not yield to pressure.
Britain Outlines Lockdown Exit as Vaccines Show 'Spectacular' Results
LONDON - British Prime Minister Boris Johnson announced plans Monday to begin easing coronavirus lockdown measures, crediting the country's rapid vaccination program for allowing Britain to begin reopening March 8. "Two weeks from today, students and pupils from all schools and further education settings can safely return to face-to-face teaching.
US to Mark Somber COVID Milestone
The United States is on the verge of half a million COVID-19 deaths, more coronavirus-related deaths than anywhere else, according to the Johns Hopkins Coronavirus Resource Center. U.S. President Joe Biden will talk about the lives lost to the virus Monday evening at the White House, followed by a moment of silence and a candle lighting ceremony.
Biden Laments 500,000 Coronavirus Deaths in US
WHITE HOUSE - As the nation marked 500,000 deaths because of COVID-19, U.S. President Joe Biden at twilight Monday walked to a White House South Portico decorated with black bunting and 500 candles. Alongside the president were first lady Jill Biden and Vice President Kamala Harris and her husband, Doug Emhoff, who is known as the second gentleman.
White House Hopes Majority of Public Schools Will Be Reopened by April
WASHINGTON - The United States is struggling to reopen its public schools across the country amid the coronavirus pandemic, but the White House said Sunday it is hoping to have full-time, in-class instruction in a majority of schools by April. “That's our goal, that's our objective, that's our plan,” White House press secretary Jen Psaki told ABC’s “This Week” show.
Israel Unveils Real-world Pfizer Data, 'Green Badge'
Israelis who have received both doses of the Pfizer-BioNTech vaccine saw their risk of illness from the coronavirus drop 98.5% and their risk of hospitalization drop 98.9%, the country’s Health Ministry said Saturday. The ministry’s findings came from data collected February 13 from a pool of about 1.7 million people who had received both shots by January 30, meaning their bodies had time to build up antibodies to the virus that causes COVID-19.
Iran Considers EU-hosted Informal Meeting With US, Official Says
DUBAI, UNITED ARAB EMIRATES - Iran is studying a European Union proposal for an informal meeting between current members of Tehran's 2015 nuclear deal and the United States, but has yet to respond to it, Iranian Deputy Foreign Minister Abbas Araqchi said Saturday. Iran and the United States have been at odds over who should take the first step to revive the 2015 accord.
WHO: ‘Growing Movement Behind Vaccine Equity’
The World Health Organization says it welcomes the recent pledges of coronavirus vaccines from several Western countries to the international health group that will help ensure an equitable allocation of vaccines to countries around the world.
Biden’s Bid to Revive Iran Nuclear Deal Faces Long Road, Should Involve US Pressure, Say Analysts
WASHINGTON - As U.S. President Joe Biden begins a diplomatic push to revive a 2015 nuclear agreement between Iran and world powers, supporters of the deal say he will need a long-term effort to succeed, while opponents say he should focus instead on pressuring Tehran into a new and tougher deal. The 2015 agreement, the Joint Comprehensive Plan of Action, or JCPOA, was reached between Iran and the five permanent members of the United Nations Security Council plus Germany, known as the P5+1.
Africa’s Coronavirus Death Toll Tops 100,000
The coronavirus death toll on the African continent surpassed 100,000 on Friday, as African countries struggled to obtain vaccines to counteract the pandemic. South Africa alone accounts for nearly half of the confirmed deaths in Africa with 48,859, according to data from the Johns Hopkins Coronavirus Resource Center. The country, which is facing its own variant of the virus, also accounts for nearly half the confirmed cases in the region, with more than 1.5 million.
Biden Tours Pfizer Vaccine Production Center
President Joe Biden toured a Pfizer COVID-19 vaccine manufacturing plant Friday afternoon outside Kalamazoo, Michigan, where he touted the safety of the vaccine. "If there's one message to cut through to everyone in this country, it's this: The vaccines are safe,” he said, according to NBC News. “Please, for yourself, your family, your community, this country, take the vaccine when it's your turn ...
Biden Announces Financial Support for Global COVID Vaccine Program
U.S. President Joe Biden announced Friday a $4 billion pledge to a global campaign to bolster the distribution of COVID-19 vaccines to poor countries. At his first meeting as president with world leaders at the Munich Security Conference, Biden announced financial support for COVAX, a coalition tasked with distributing vaccines to low- and middle-income countries.
Biden Says Iran Talks Needed to Avoid Mistakes in Mideast
U.S. President Joe Biden said Friday that the United States was driven to “reengage in negotiations” to revive a 2015 nuclear deal with Iran by the desire to avoid missteps that could further destabilize the Middle East. “We need transparency and communication to minimize the rise of strategic misunderstanding or mistakes,” Biden said at the virtual Munich Security Conference.
UAE Probe Successfully Begins Orbit of Mars
The United Arab Emirates (UAE) space agency announced Tuesday that its unmanned Mars probe has arrived at the red planet and successfully entered orbit. The Emirates Mars Mission — known as the Amal, or Hope Probe — announced the arrival from its official Twitter account. "Success! Contact with #HopeProbe has been established again. The Mars Orbit Insertion is now complete," the tweet said.
WHAT DO YOU DO WITH FORCE AFTER YOU WIN?
We don’t have a sophisticated genre about what do militaries do in the wake of victory What is the role of the military in consolidating victory? This has been a difficult question at least since World War II and is very salient now. A BETTER PEACE explores this topic with the help of Dr. Wayne Lee, the Dowd Distinguished Professor of History at the University of North Carolina at Chapel Hill, and Dr. Jacqueline E. Whitt, U.S. Army War College Professor of Strategy.
US Troops to Withdraw From Somalia Amid Ongoing Terror Threat
The United States is pulling hundreds of troops deployed to Somalia to battle al-Shabab terrorists even as military commanders admit the threat from the al-Qaida-linked terror group has not been eliminated. "A threat remains," Africa Command spokesman Colonel Chris Karns told VOA following the announcement late Friday that President Donald Trump had ordered U.S. forces to leave Somalia.
Biden Pledges to Unify, Not Divide US in Address to Nation
WASHINGTON - Former U.S. Vice President Joe Biden, the projected winner of the U.S. presidency, pledged to be “a president who seeks not to divide, but unify” the country during an address to the nation Saturday night from Wilmington, Delaware.
Joe Biden Is Projected Winner of US Presidential Election Original
WASHINGTON - Former U.S. Vice President Joe Biden, a fixture in Washington political circles for nearly a half century, has been projected as the winner of the U.S. presidency and stands to be inaugurated on January 20, 2021.
More Than 1 Million US Muslims Now Registered to Vote
WASHINGTON - More than one million American Muslims have registered to vote in the November 8 U.S. elections, a record number that puts the community in a position to tip the race in states where they live in large numbers as polls show a tightening contest, Muslim advocates said on Wednesday.
US Launches Next-Generation Rover to Mars
The U.S. has launched its next-generation Mars rover in search of potential signs of life on the red planet. NASA’s latest rover, Perseverance, launched at 11:50 GMT Thursday from Cape Canaveral in the southeastern state of Florida. The robotic explorer was propelled into space by an Atlas 5 rocket operated by the United Launch Alliance, a joint venture between private aerospace companies Boeing and Lockheed.
What does “work on a real problem” mean for prospective data scientists?
Breaking down the expectations around the most common advice If you ask any data science hiring manager for interview advice, they’ll tell you to work on a real problem and upload your code/presentation online. It’s hard to argue against this since who doesn’t want someone who can already do the job? To a student (undergrad or PhD) without any experience, however, this advice is frustrating. The dark secret is that most hiring managers cannot tell you exactly what they’re looking for either.
White House Defends Decision to Shelve Coronavirus Reopening Plan
The Trump administration is defending its decision not to release a detailed coronavirus reopening plan for the U.S., maintaining they would have been too narrowly-focused for the country’s 50 states. The administration’s defense comes in response to an Associated Press report that it shelved a report prepared by senior U.S. disease investigators detailing how and when local authorities should begin to reopen businesses and other public places during the current coronavirus crisis.
US Stocks Fall Amid Pandemic Concerns
U.S. stocks fell sharply Friday, despite congressional approval of a $2.2 trillion economic stimulus bill, as world economies continued to grapple with containing the coronavirus pandemic. The Dow Jones industrial average fell nearly 4.1%, while the S&P 500 dropped 3.4% and the Nasdaq Composite Index was down 3.8%. Stocks rallied earlier this week after the Senate approved the stimulus package to try to blunt the economic impact of the pandemic and provide assistance directly to Americans.
US Lawmakers Agree to Bipartisan Bill to Combat Coronavirus
Lawmakers in Washington reached a bipartisan agreement Wednesday to provide $8.3 billion in emergency funding to combat the rapid spread of the coronavirus in the U.S. Democratic and Republican leaders in the Senate and the House of Representatives agreed to the funding bill and hope a final version of the measure clears Congress by the end of the week. Final passage would be a bipartisan achievement that is now uncommon in Washington’s polarized political climate.
Coronavirus: Points to consider on M&A transactions | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Trump's Lawyers Defend Him at Senate Impeachment Trial
WASHINGTON - U.S. President Donald Trump’s legal team gave opening statements Saturday in the Senate after House managers wrapped up three days of arguments in Trump’s historic impeachment trial. White House counsel Pat Cipollone began presenting Trump’s defense by declaring the Democratic House managers had failed to achieve their objective. “We don’t believe that they have come anywhere close to meeting their burden for what they’re asking you to do,” Cipollone said.
Myanmar Panel: War Crimes But No Genocide Committed Against Rohingya
An independent panel created by the Myanmar government has concluded that government security forces committed war crimes against Rohingya Muslims but that they did not commit genocide against the ethnic minority. The findings were included in a report released Monday by the Independent Commission of Inquiry.
Senior White House Official Testifies Privately in Trump Impeachment Probe
WASHINGTON - A senior White House budget official arrived on Capitol Hill Saturday to testify behind closed doors before congressional investigators who are conducting an impeachment inquiry against U.S. President Donald Trump. Mark Sandy, a longtime career official with the Office of Management and Budget, is the first agency employee to be deposed in the inquiry after three employees appointed by Trump defied congressional subpoenas to testify.
Ex US Ambassador to Ukraine Felt 'Threatened' After Being Ousted
The ousted former U.S. ambassador to Ukraine, Marie Yovanovitch, testified Friday at the congressional impeachment inquiry into U.S. President Donald Trump that she was “shocked and devastated” over remarks Trump made about her during a call with Ukrainian President Volodymyr Zelenskiy. “I didn’t know what to think, but I was very concerned,” she told the House Intelligence Committee on Capitol Hill in Washington.
Lebanese Banks Reopen After 2-Week Closure Due to Anti-Government Protests
AMMAN, JORDAN - Lebanese banks reopened Friday after closing two weeks ago amid nationwide anti-government protests that have crippled the country. Much of the protesters’ ire has been directed at the banks, which they perceive to be part of the political establishment that has been accused of rampant corruption and the provision of poor public services.
China removes more barriers to market entry | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
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