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Weang Kee Ho

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Articles

Genomic platform specific polygenic risk scores impact breast cancer risk stratification - Communications Medicine

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By Peh Joo Ho, Alexis Khng, Pierre-Alexis Goy, Kayla Aisha Kamila, Zheng Li, Weang Kee Ho, Dawn Qingqing Chong, Elaine Ah-Gi Lo, Liuh Ling Goh, Hwee Lin Wee, Mikael Hartman, Rajkumar Dorajoo, Nicolas Bertin, Jingmei Li
| Nature Verified
Abstract At present, there is no consensus on which genotyping platform should serve as the standard for clinical polygenic risk score (PRS) implementation. Previous studies have compared the overall performance and concordance of different genotyping and sequencing technologies; however, these analyses have generally averaged the results over the whole genome. We evaluated differences in a 313-variant breast cancer PRS (PRS313) across genomic platforms and their impact on risk stratification.
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Predicting the Likelihood of Carrying a BRCA1 or BRCA2 Mutation in Asian Patients With Breast Cancer

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By Weang Kee Ho, Eldarina Wijaya, Pei Sze Ng, Siti Norhidayu Hasan
| ascopubs.org
Boon Hong Ang, PhD1; Weang Kee Ho, PhD1,2; Eldarina Wijaya, MSc1; Pui Yoke Kwan, BSc1; Pei Sze Ng, PhD1; Sook Yee Yoon, MA1; Siti Norhidayu Hasan, Dip1; Joanna M.C. Lim, PhD1; Tiara Hassan, MGenCouns1; Mei-Chee Tai, PhD1; Jamie Allen, MSc3; Andrew Lee, PhD3; Nur Aishah Mohd Taib, MS, MBBS4,5; Cheng Har Yip, MBBS6; Mikael Hartman, MD, PhD7; Swee Ho Lim, MBBS, MMed8; Ern Yu Tan, MBBS, MMed, DPhil9,10,11; Benita K.T. Tan, MBBS, MMed, PhD12,13,14; Su-Ming Tan, MBBS, MMed15; Veronique K.M. Tan,...
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Predicting the Likelihood of Carrying a BRCA1 or BRCA2 Mutation in Asian Patients With Breast Cancer

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By Weang Kee Ho, Pei Sze Ng, Eldarina Wijaya, Siti Norhidayu Hasan
| ascopubs.org
Abstract With the development of poly (ADP-ribose) polymerase inhibitors for treatment of patients with cancer with an altered BRCA1 or BRCA2 gene, there is an urgent need to ensure that there are appropriate strategies for identifying mutation carriers while balancing the increased demand for and cost of cancer genetics services.
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