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Prostate cancer is a high-incidence male cancer that progresses to metastatic disease in a subset of diagnosed cases. Early detection of high-risk disease is a key translational challenge and if successful will reduce overtreatment while potentially improving the outcomes for those patients most in need of early interventions. There are many challenges that need to be surmounted to achieve this translational outcome, not least the fact that prostate cancer is a multi-focal disease.
DNA damage arises either due to cellular exposure to exogenous sources of damaging agents such as chemotherapy or because of a failure to repair endogenous DNA damage in cells (Jackson and Bartek, 2009). DNA damage itself can take many different forms depending on the mechanism of action of the agent used (Box 2), with DNA double-strand breaks (DSBs) considered to be the most cytotoxic to cancer cells (Brown et al, 2017).
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