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Wei Jia Goh on Muck Rack

Wei Jia Goh

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Articles

Actin based cell chirality emerging at the boundary of 2D-microtissue directs chiral multicellular pattern formation

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By Wenzheng Shi, Hui Ting Ong, Chaoyu Fu, Alexander D. Bershadsky, Alex Mogilner, Wei Jia Goh
| Nature Verified
Abstract The mechanisms underlying both the establishment of mirror (reflection) symmetry and deviations from it in the development of bilateral multicellular organisms remain insufficiently understood. Actin cytoskeletons of individual cells exhibit intrinsic chirality, and a strong correlation exists between single-cell actin fibres’ chiral organisation and the collective alignment of cells confined to rectangular adhesive islands (2D-microtissues).
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