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Wei Ting C. Lee on Muck Rack

Wei Ting C. Lee

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Articles

Positional replication fork instability drives PARP inhibitor cytotoxicity

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By Dipika Gupta, Xia Ding, Lianglin Zhang, Kate Coleman, Grace J Tang, Jon Oyer, Xiaolin Kang, Dana J. Ramms, Ziqi Yu, Todd L. VanArsdale, David Fenyö, Tony T. Huang, Eli Rothenberg, Wei Ting C. Lee
| Nature Verified
Abstract Although poly(ADP-ribose) polymerase inhibitors (PARPi) show promise for treating homologous recombination-deficient cancers, the observed PARPi hypersensitivity in additional genetic contexts expands their potential use in precision oncology. Yet, the DNA lesions driving PARPi-induced cytotoxicity remain poorly defined. Here we uncover distinct replication-fork lesions in specific genomic regions as key determinants of PARPi cytotoxicity.
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