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Abstract Cleft lip and palate (CLP) are common congenital craniofacial anomalies, but the post-transcriptional mechanisms regulating palatal shelf growth remain incompletely understood. In this study, small RNA sequencing was used to profile miRNA expression during murine palatal shelf development, and miR-124-3p was selected for functional assessment. In situ hybridization detected miR-124-3p in palatal tissues at multiple embryonic stages.
Abstract Toothbrushing is a fundamental oral hygiene behavior associated with differences in the composition of salivary microbiome, yet whether its relationship with microbial profiles differs across oral conditions remains unclear. In this study, 300 participants were initially enrolled, including healthy controls and patients with dental caries or dental fluorosis (100 per group). After exclusion of one fluorosis sample that failed sequencing, 299 unstimulated saliva samples were analyzed.
Abstract Objective: This study aims to explore the effects of indirect moxibustion combined with Ma Ren Pill on the time to resolution of constipation and respiratory symptoms, hospitalization duration, lung function, blood gas indicators, inflammatory factors, clinical efficacy, quality of life, and the incidence of adverse reactions in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) accompanied by constipation.
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