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Weijiang Ying on Muck Rack

Weijiang Ying

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Articles

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

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By Shirish Shukla, Felicia Gray, Weijiang Ying, Yiwu Yao
| Nature Verified
Abstract Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1 activity in various cancers, rationalizing the need for small-molecule inhibitors with well-defined mechanisms of action. Here, we describe the development of compounds that directly bind to RING1B–BMI1, the heterodimeric complex constituting the E3 ligase activity of PRC1.
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