Weikang Xu

Abstract Bone defects resulting from trauma, tumors, or infection continue to pose significant clinical challenges, particularly when the defect size exceeds the capacity for spontaneous healing. In this study, we fabricated two types of composite scaffolds—calcium carbonate/mesoporous silica/poly(lactic-co-glycolic acid) (CMP) and mesoporous silica/poly(lactic-co-glycolic acid) (MP)—using a single-emulsion solvent evaporation method.

Skip to main content Intended for healthcare professionals Restricted access Research article Get full access to this article View all access and purchase options for this article. References 1. Migliorini F, La Padula G, Torsiello E, et al. Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature. Eur J Med Res 2021; 26(1): 118. 2. Nik Md Noordin Kahar NNF, Ahmad N, Jaafar M, et al.

1. Introduction Click to copy section linkSection link copied! With more than 10 million patients suffering from bone defects and bone injuries worldwide each year, a large demand exists for bone repair products. Autologous and allogeneic bone grafts are the gold standard for repairing bone defects exceeding critical dimensions. However, the obvious drawbacks of these methods, such as donor site pain, bleeding, and limited sources, limit their clinical application.