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Articles by Weiling He
MASP1‑METTL3‑HAS2 axis aggravates liver fibrosis through HMW‑HA‑mediated senescence inhibition and LMW‑HA‑induced activation of hepatic stellate cells
Abstract The hepatic microenvironment undergoes dynamic remodelling in advanced liver fibrosis. Hyaluronic acid (HA), a key component of this fibrotic microenvironment, plays a key role in disease progression. While cellular senescence is one of the fates that activated HSCs undergo and is associated with fibrosis resolution, the relationship between HA and HSC senescence in advanced liver fibrosis remains unclear.
AI in predicting the macrotrabecular-massive subtype of HCC and informing treatment selection: a multi-center and prospective validation study
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Abstract The macrotrabecular-massive (MTM) subtype of hepatocellular carcinoma (HCC) is associated with aggressive biology and poor prognosis. We aimed to develop a CT-based artificial intelligence model (DeepCT-MTM) for the noninvasive prediction of MTM-HCC and investigate its prognostic utilities as well as biological underpinnings. A total of 3118 patients with HCC were included from 20 tertiary-care hospitals.
By Ran Wei, Hanyu Jiang, Mengxuan Zuo, Xuelei He, Fei Cao, Shaolong Li, Wang Li, Wendao Liu, Chengzhi Li, Xin Li Verified, Jianjun Han, Dong Yan, Weiling He, Feng Duan, Xinya Zhao
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Nature
Verified
AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer
Abstract While ferroptosis induction offers promising avenue for cancer therapeutics, its clinical utility in colorectal cancer (CRC) is limited by pervasive intrinsic resistance mechanisms. Here, we identify Aurora kinase A (AURKA) as a central suppressor of ferroptosis by rewiring cholesterol metabolism. Mechanistically, AURKA phosphorylates and destabilizes its negative regulator SAPS3 at Ser523/524, relieving AMPK suppression.
The lncRNA DAMER selectively guides m6A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer - Nature Cell Biology
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Abstract How cancer cells couple metabolic stress sensing to orchestrate specific survival programmes is a key question. Here we show a long non-coding RNA (lncRNA)-guided epitranscriptomic mechanism orchestrating metabolic adaptation by controlling the stability of master stress regulator ATF4. Glucose or glutamine deprivation induces endoplasmic reticulum stress via reactive oxygen species–NRF2-dependent transcription of the lncRNA DAMER.
By Yi Yang, Bangdong Liu, Jiaer Liang, Zishuo Chen, Shuqi Wang, Jiaqi Zhao, Xiuxiu Yang, Liyun Huo, Youhong Zhang, Zhen Gan, Weibin Wu, Jiayu Zeng, Yi Huang, Xuemei Xu, Jianchen Yu, Hongyu Guan, Jueheng Wu, Laixin Xia, Weiling He, Junchao Cai, Mengfeng Li, Tianyu Tao, Xianming Feng, Yaokai Ye, Ruohui Hong
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Nature
Verified
Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers - Nature Communications
Abstract Non-nucleotide stimulators of interferon gene (STING) agonists hold promise as immunotherapeutic agents for postsurgical adjuvant treatment of tumors. However, their limited effect duration hampers therapeutic effectiveness, necessitating prolonged administration of multiple doses that heightens infection risk and impacts patient compliance.
Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach - Nature Communications
Abstract Epitranscriptomic modifications, particularly N6-methyladenosine (m6A), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and translation. Traditional computational methods for detecting m6A from Nanopore direct RNA sequencing (DRS) data are constrained by their reliance on experimentally validated labels, often resulting in the underestimation of modification sites.
The Effect of Oxidative Phosphorylation on Cancer Drug Resistance
Abstract : Simple Summary Drug therapy is an important treatment for cancer patients; however, drug resistance severely affects the survival time and quality of life of cancer patients. Oxidative phosphorylation (OXHPOS) is an important metabolic process in cells that drives cancer drug resistance and exerts a significant influence on responses to anticancer therapy. Targeting OXPHOS can specifically eliminate cancer stem cells and delay the acquisition of drug resistance.
CD155T/TIGIT Signaling Regulates CD8+ T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer
AbstractThe T-cell surface molecule TIGIT is an immune checkpoint molecule that inhibits T-cell responses, but its roles in cancer are little understood. In this study, we evaluated the role TIGIT checkpoint plays in the development and progression of gastric cancer. We show that the percentage of CD8 T cells that are TIGIT+ was increased in gastric cancer patients compared with healthy individuals.
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