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Weilv Xu on Muck Rack

Weilv Xu

As seen in: Nature, BioRxiv
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Articles

Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing - Nature Communications

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By Weilv Xu, Aijuan Qu, Shuxian Chen, Peng Gong, Bo Shan, Hui Shi
| Nature Verified
Abstract The gut microbiota sustains intestinal homeostasis, yet how microbial metabolites direct epithelial repair remains unclear. Here we identify indole-3-propionic acid (IPA), a tryptophan-derived bacterial metabolite, as a key regulator of mucosal healing. IPA activates PPARα in intestinal epithelial cells, enhancing transcription of the ketogenic enzyme HMGCS2 and boosting β‑hydroxybutyrate (BHB) production.
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Diverse Strategies Utilized by Coronaviruses to Evade Antiviral Responses and Suppress Pyroptosis

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By Xinyu Fu, Weilv Xu, Danyue Li, Xinyue Li
| BioRxiv
Abstract Viral infection triggers inflammasome-mediated caspase-1 activation. Nevertheless, limited understanding exists regarding how viruses use the active caspase-1 to evade host immune response. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of coronaviruses (CoVs) to illustrate the intricate regulation of CoVs to combat IFN-I signaling and pyroptosis.
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Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis - Cell Death & Disease

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By Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Lu Dong, Yuqi Yan, Suhui He
| Nature Verified
Abstract Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely unexplored. In this study, we demonstrate that GSDMD can undergo acetylation at the Lysine 248 residue, and this acetylation enhances pyroptosis.
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