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Weimin Ye

As seen in: Nature, Wiley Online Library, PLOS ONE, Frontiers in Public Health, JAMA (The Journal of the American Medical Association), Cell Reports Medicine, International Journal of Epidemiology, Canadian Journal of Infectious Diseases & Medical Microbiology, Cancer Epidemiology, Biomarkers & Prevention, Neurology
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Articles

Vitamin D receptor isoform VDRA suppresses hepatocellular tumorigenesis by restricting YAP nuclear localization

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By Lizhi Li, Shiwei He, Jianbin Wang, Ziyi Zheng, Zhe Wang, Bingyan Li, Weimin Ye, Ping Wang, RuoYa Wang
| Nature Verified
Abstract Hepatocellular carcinoma (HCC) frequently arises from uncontrolled proliferation of hepatocyte epithelium, a process potently driven by the transcriptional regulator yes-associated protein (YAP). Although 1,25(OH)₂D₃, the active form of vitamin D, exerts established anti-proliferative effects through its receptor (VDR), the specific roles of its two principal isoforms, VDRA and VDRB1, have remained largely undefined.
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EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk

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By Yanhong Chen, Jingtong Liang, Wanlin Zhang, Xinyu Zhang, Xinyi Zhang, Ching-Yuan Wang, Fei Yao, Shanshan Zhang, Xiang Zhou, Weimin Ye, Ruimei Feng, Yonglin Cai, Zhe Zhang, Mingfang Ji, Qian Cui, Xihong Lin, Jiesen Li, Jialei Xu, Qiuting Zhang, Yingying Cheng, Yanran Luo, Xiaoping Ye, Qisheng Feng, Minzhong Tang, Mu-Sheng Zeng, Yi-Xin Zeng, Zhonghua Liu, Weiwei Zhai, Jianjun Liu, Miao Xu, Qinyao Huang
| Nature Verified
Abstract Epstein–Barr virus (EBV) infects more than 95% of adults worldwide but is associated with endemic nasopharyngeal carcinoma (NPC) specifically in southern China1,2,3,4. Here, through a stepwise host–EBV genome interaction analysis, we identify a genetic interaction between HLA-A*11:01 and the high-risk EBV variant 85841G as a key determinant of NPC risk.
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City- and county-level gaps in diabetes mortality improvement in the southeastern coastal region of China from 2005 to 2020, with provincial-level projections to 2030

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By Xiuquan Lin, Chenglin Yang, Yuying Chen, Wenling Zhong, Weimin Ye, Shaofen Huang, Yanrong Yin
| Frontiers in Public Health Verified
Abstract Objectives: The growing health and economic burden of diabetes in China is a result of fast urbanization and lifestyle changes. This highlights the critical need for a comprehensive analysis of epidemiological patterns and forecasts in order to achieve the “Healthy China 2030” goals. Methods: Socio-Demographic Index (SDI) factors were used to evaluate data on diabetes mortality and YLL (2005–2020) for adults in 84 Fujian counties.
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