Weipai He on Muck Rack

Weipai He

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M 6 A-dependent upregulation of ZNF460 promotes epithelial-mesenchymal transition and metastasis of gastric cancer through a histone modification-mediated positive feedback loop

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By Ben Yue, Chenlong Song, Tianshang Bao, Jin Du, Linxi Yang, Enhao Zhao, Zizhen Zhang, Weipai He
| Nature Verified
Abstract The regulatory role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of N6-methyladenosine (m6A) in TGF-β signaling remains obscure. Here, we unveil, for the first time, the m6A modification profile in TGF-β-induced gastric cancer (GC) EMT and identify zinc finger protein ZNF460 as a critical mediator of the EMT process.
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