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Weiren Lan

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UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

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By Xueman Chen, Huai Yu, Jianzhao Ruan, Weiren Lan
| Wiley Online Library Verified
1 Introduction Osteoarthritis (OA) is the most common musculoskeletal disease in humans, impacting at least 654 million individuals globally with increasing prevalence.[1] Currently, it poses a huge health and economic burden, especially on the elderly.[2] The pathogenesis of OA encompasses the activation of diverse inflammatory signaling cascades, notably including the NF-κB and mitogen-activated protein kinase (MAPK) pathways,[3, 4] which regulate the release of pro-inflammatory cytokines...
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