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Weitong Wang

As seen in: BioRxiv
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Articles

Inhibition of GEF-H1-RhoA signaling in inflammation with a stapled peptide mimicry of the RhoA67-78 helix

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By Tiansheng Liu, Weitong Wang, Clara Gathmann, Shuhuai Yang
| BioRxiv
Abstract Guanine exchange factors (GEFs) are considered hard to drug with conventional small molecules, they lack conventional deep binding pockets and binding ligands are seldom reported. Here we report the design of a stapled peptide stP5 targeting the interaction between cytoskeletal regulator RhoA GTPase and its activator guanine exchange factor H1 (GEF-H1). StP5 is a modified RhoA mimic based on a previously identified bioactive α-helical epitope to GEF-H1.
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Temporal and spatial variations of soil C, N contents and C:N stoichiometry in the major grain-producing region of the North China Plain

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By Huan Yang, Xuan Song, Yun Zhao, Weitong Wang
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Huan Yang, Xuan Song , Yun Zhao, Weitong Wang, Zhennan Cheng, Qi Zhang, Daoquan Cheng Huan Yang, Xuan Song, Yun Zhao, Weitong Wang, Zhennan Cheng, Qi Zhang, Daoquan Cheng Published: June 11, 2021 https://doi.org/10.1371/journal.pone.0253160 Figures Abstract Soil C, N contents and C:N stoichiometry are important indicators of soil quality, the variation characteristics of which have great significance for soil carbon-nitrogen cycle and...
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