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Abstract Background: Hyperphosphataemia is consistently linked to adverse clinical outcomes in Acute Kidney Injury (AKI). Sevelamer, a non-calcium phosphate binder widely used in chronic kidney disease (CKD), has not been adequately evaluated for efficacy in AKI. Methods: We performed a retrospective cohort analysis in the MIMIC- IV database. The association between sevelamer exposure and 28- day all-cause mortality was estimated using multivariable Cox models and propensity score matching (PSM).
Abstract Limited immune cell infiltration is the main reason for poor immunotherapeutic efficacy in colorectal cancer patients. Here we design a peptide-based nanorobot that recognizes PD-L1 and breaks cancer cell membranes by in situ forming fibrils through a pH-responsive module. The nanorobot shows long retention in targeted tumours (>120 h) through interaction with PD-L1 and blocks PD-1/PD-L1 to activate the T cell killing effect.
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “Macrolactin R From Bacillus siamensis and Its Antifungal Activity Against Botrytis cinerea,” World Journal of Microbiology and Biotechnology 39, no. 5 (2023): 117–122. 2, , , , , and , “Resistance to Boscalid in Botrytis cinerea From Greenhouse-Grown Tomato,” Plant Disease 105, no. 3 (2021): 628–635.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
