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Weiyin Wu on Muck Rack

Weiyin Wu

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Articles

Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice

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By Mengdan Wang, Xiaoxuan Yu, Shiyao Zhang, Xiao Yu Wu, Yan Wang, Shuo Zhang, Tursunjan Aziz, Weiyin Wu
| Nature Verified
Abstract Cognitive impairment affects 30%–80% of patients with heart failure, yet the mechanisms beyond reduced brain blood flow remain poorly defined. Here we show that circulating factors released during heart failure trigger senescence of brain blood-vessel endothelial cells, which in turn drives synaptic loss and cognitive decline through crosstalk between endothelial cells and microglia, the brain’s immune cells.
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