Wen-Bing Yin

Scaffold modification, including late-stage oxidative tailoring, enables biosynthetic pathways to generate structurally distinct products from closely related intermediates. (1,2) Usually, even a single oxygenation event can alter product structure. Flavin-dependent monooxygenases (FMOs) often play important roles in these processes by epoxidation or hydroxylation. (3−7) This is particularly relevant for pathways that produce closely related metabolites differing only in oxidation state.

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