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Wen-Ying Chao on Muck Rack

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IJMS | Free Full-Text | In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis | HTML

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By Ying-Ray Lee, Shu-Hsin Chen, Ching-Yen Lin, Wen-Ying Chao
| MDPI
In this study, we investigated the in vitro antitumor effect of aloperine on various types of human thyroid cancer cells. We found that aloperine could inhibit cellular proliferation and also reduce the tumorigenesis of cells of multidrug-resistant human papillary thyroid carcinoma and in ATC. Further analysis demonstrated that intrinsic and/or extrinsic caspase-dependent apoptosis was elevated and the Akt signaling pathway was involved in aloperine-mediated cellular apoptosis.
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