Highlights (3 to 4 main points) • Broadly-reactive neutralizing antibodies (nAbs) may overcome SARS-CoV-2 variant escape • mRNA display is used to rapidly identify SARS-CoV-2 spike (S) protein-directed nAbs • Structural studies reveal distinct binding modes for several identified antibodies • An engineered nAb sustains binding to variant Gamma E484K and Delta L452R spike Summary The increasing prevalence of SARS-CoV-2 variants with the ability to escape existing humoral protection conferred...
