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Wendy Sandoval on Muck Rack

Wendy Sandoval

As seen in: AIChE Journal, Nature
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Articles

The discovery and structural basis of two distinct state-dependent inhibitors of BamA - Nature Communications

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By Kelly M. Storek, Dimitry Tegunov, John Quinn, Wayne J. Fairbrother, Wendy Sandoval, Claudio Ciferri, Christian N. Cunningham, Steven T. Rutherford
| Nature Verified
Abstract BamA is the central component of the essential β-barrel assembly machine (BAM), a conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the outer membrane of Gram-negative bacteria. Despite recent advances in our mechanistic and structural understanding of BamA, there are few potent and selective tool molecules that can bind to and modulate BamA activity.
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Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle

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By Danming Tang, Wendy Sandoval, Peter Liu, Cynthia Lam
| AIChE Journal Verified
RESEARCH ARTICLE Danming Tang, Corresponding Author tangd10@gene.com orcid.org/0000-0002-7199-743X Cell Culture and Bioprocess Operations Department, Genentech Inc., South San Francisco, California, USA Correspondence Danming Tang and Shahram Misaghi, Cell Culture and Bioprocess Operations Department, Genentech Inc., South San Francisco, CA, USA. Email: tangd10@gene.com (D. T.) and smisaghi@gene.com (S.
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Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants

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By Jia Jie Tang, Wendy Sandoval, Bingchuan Wei, Guanghui Han
| American Chemical Society
Recombinant monoclonal antibodies (mAbs) are one of the most important classes of biotherapeutics in various fields including cancer,(1,2) autoimmune diseases,(3) neurological diseases,(4) and infectious diseases.(5) Immunoglobulin G (IgG) is the dominant form of the mAb drugs among five classes of human antibodies.(6,7) IgGs have complicated, heterogeneous, and dynamic structures.
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