Wenhao Yin

B(C6F5)3 Catalysed Cyclic Carbonate Editing† We reported an unusual Lewis acid catalyzed cyclic carbonate editing approach. Such a CO2-retention and metal-free process could be performed at room temperature with 100% atom economy. The products incorporated tetra-substituted stereodefined alkenyl moiety which are synthetically challenging or economically consuming via otherwise methods. DFT calculations detailed the reaction pathways and the origin of excellent steroselectivity.

1 Introduction Vitiligo, a condition characterized by white patches on the skin, is an autoimmune disease [1, 2]. The localized or generalized depigmented lesions are a result of the reduction or absence of functional melanocytes in the skin and hair follicles [3]. Pathogenesis is unclear and is related to genetic and nongenetic factors [4-6]. Vitiligo is a prevalent condition that may affect various regions of the body and manifest at any age [7].

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