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Wenqu Yin

As seen in: BioRxiv, eLife
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Articles

Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

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By Wenqu Yin, Xin Wang, Jiawen Li, Shanglin Zhou
| eLife
eLife Assessment This useful study reports how neuronal activity in the prefrontal cortex maps time intervals during which animals wait to reach a reward, with this mapping remaining consistent across days. While most claims are supported by solid evidence, the study could have benefitted from an improved experimental design to more clearly disambiguate correlations between neuronal patterns and not only time but also stereotypical behaviors and restraint from impulsive decisions.
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Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

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By Jiawen Li, Shanglin Zhou, Wenqu Yin, Chao-Lin Ma
| BioRxiv
Abstract Time estimation is an essential prerequisite underlying various cognitive functions. Previous studies identified sequential firing and activity ramps as the primary neuron activity patterns in the medial frontal cortex (mPFC) that could convey information regarding time. However, the relationship between these patterns and the timing behavior has not been fully understood. In this study, we utilized in vivo calcium imaging of mPFC in rats performing a timing task.
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