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Articles by Wenteng Chen
Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5
Abstract Inducing protein oligomerization holds therapeutic promise, yet identifying or rationally designing effective inducers remains challenging. In this study, we leverage nanopore technology to screen small molecules capable of modulating WD repeat domain 5 (WDR5) protein oligomerization and uncover a oligomerization mechanism which we term Catalytic Proximal Protein Oligomerization (CaPPO).
Advancing Target-Based Drug Design Strategy Learning in the Third-Year Pharmaceutical Science Undergraduates: Design, Synthesis and Biological Activity Evaluation of EGFR Inhibitors
Ayuda Buscar en la ayuda Buscar en la ayuda Advancing Target-Based Drug Design Strategy Learning in the Third-Year Pharmaceutical Science Undergraduates: Design, Synthesis and Biological Activity Evaluation of EGFR Inhibitors Huazhou Ying [1] ; Wenteng Chen [1] ; Sunliang Cui [1] [1] Zhejiang University, China Localización: Journal of chemical education, ISSN 0021-9584, Vol. 102, Nº 9, 2025, págs.
Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH
Keywords MASH iron chelator iron metabolism ferroptosis FerroTerminator1 FOT1 ACSL4 c-MYC serum ferritin liver disease Introduction The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD),1 1. Lazarus, J.V. ∙ Mark, H.E. ∙ Allen, A.M. ... A global research priority agenda to advance public health responses to fatty liver disease J. Hepatol.
Mild and facile synthesis of Formamide: Reduction and functionalization of CO2 using NaBH(OAc)3 under atmospheric pressure
Mild and facile synthesis of Formamide: Reduction and functionalization of CO2 using NaBH(OAc)3 under atmospheric pressure An approach for N-formylation of amines was developed using NaBH(OAc)3 as reductant under atmosphere pressure of CO2 at 50 oC. The corresponding formylated products of various amines, including aliphatic and aromatic amines, amines with reductive-sensitive nitro groups and alkynyl groups as well as benzamide were obtained in good to excellent yields.
New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes
New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes Autofluorescing Carboline-Fluors were efficiently and rationally developed via a Pictet-Spengler involved one-pot multi-component reaction. The Carboline-Fluors demonstrate specific targeting the endoplasmic reticulum in living cells, superior sensitivity than commercial ER-Trackers.
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