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Yingying Yu on Muck Rack

Yingying Yu

As seen in: Environmental Health Perspectives, Color Research & Application, Nature, Wiley Online Library, PLOS, BMJ Open, Frontiers, Frontiers in Immunology, Frontiers in Public Health, MDPI and
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Articles

Zinc accumulation in macrophages exacerbates metabolic dysfunction-associated steatotic liver disease progression

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By Jiahui Zhou, Xinhui Wang, Wen-Yue Liu, Yingying Yu, Shujie Wang, Ziqin Yao, Zijun Song, Enjun Xie, Yi Yang, Shumin Sun, Xiaotian Wu, Junxia Min, Fudi Wang, Wanru Zheng, Pinanong Na Phatthalung, Li-You Lian
| Nature Verified
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 1 billion people globally, yet the role of trace elements in its progression remains poorly defined. Here, we identify “macrophage zinc trapping” (i.e., selective zinc accumulation in hepatic macrophages despite systemic zinc depletion) as a critical driver of MASLD. In a cohort of 1069 individuals with MASLD, we found that serum zinc levels were inversely correlated with the disease severity.
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Brown fat-specific RNA labelling reveals a network of inter-organ communication by secreted microRNAs

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By Marsel Lino, Vissarion Efthymiou, Alice Rodrigues, Allah nawaz, Anindya Ghosh, Bruna Brasil Brandao, Yoshiyuki Watanabe, Rafael Salgueiro, Yingying Yu, C. Ronald Kahn, Gabriel Palermo-Ruiz, Shraddha Bhonsle
| Nature Verified
Abstract Extracellular microRNAs (miRNAs) are emerging as key regulators of organismal homeostasis. Here, using tissue-specific RNA labelling based on uracil phosphoribosyltransferase-mediated incorporation of 4-thiouracil in male mice, we develop a roadmap of miRNA transfer from brown adipose tissue (BAT) to other tissues, where they can act to regulate energy metabolism.
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Digital government and residents’ mental health in China: evidence on potential mechanisms and urban–rural heterogeneity

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By Hao Ji, Xianguo Qu, Junyi Xin, Yingying Yu, Weiguang Pan
| Frontiers in Public Health Verified
Abstract Background: Digital government has become a critical component of contemporary public governance, yet its relationship with residents’ mental health remains insufficiently examined. This study investigates whether digital government development is associated with residents’ mental health in China and how this association varies across urban and rural populations.
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