Wenzhen Yin

Abstract Introduction: Beyond its primary digestive functions, the stomach serves as an endocrine organ, secreting peptides that regulate appetite and energy balance. Among its enteroendocrine populations, X/A-like cells play a pivotal role in controlling food intake, glucose homeostasis, and lipid deposition. The secretion of X/A-like cell-derived hormones, including ghrelin and nesfatin-1, is regulated by the mechanistic target of rapamycin (mTOR) signaling pathway.

Open AccessArticle by Yunhua Zhang 1,2,†, Ziming Zhu 1,†, Lijun Sun 1, Wenzhen Yin 1, Yuan Liang 1, Hong Chen 1, Yanghui Bi 1, Wenbo Zhai 1, Yue Yin 3,* and Weizhen Zhang 1,* 1 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing 100191, China 2 The Key Laboratory of Xinjiang Endemic & Ethnic Diseases and Department of Biochemistry, Shihezi University School of...

Current therapy for pancreatic cancer is often ineffective. Our study demonstrates that RYGB surgery holds promise for the intervention of this malignancy. When performed before the development of pancreatic ACC at the age of 16 weeks, RYGB surgery is sufficient to block the spontaneous occurrence of pancreatic neoplasia in both Ngn3-Tsc1−/− male and female mice. No cancer was observed in pancreas or liver and kidney in Ngn3-Tsc1−/− transgenic mice up to the age of 300 days.