Werner Theodor Jauslin

Correction: A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα Correction for ‘A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3Kα’ by Werner Theodor Jauslin et al., Chem. Sci., 2024, https://doi.org/10.1039/D3SC04629J. This article is Open Access This article has not yet been cited.

A high affinity pan-PI3K binding module supports selective targeted protein degradation of PI3KᆠClass I phosphoinositide 3-kinases (PI3Ks) control cellular growth, but are also essential in insulin signaling and glucose homeostasis. Pan-PI3K inhibitors thus generate substantial adverse effects, a reality that has plagued drug development against this target class.