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Wes LaBarge on Muck Rack

Wes LaBarge

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Articles

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis - Nature Communications

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By Jennifer Duffen, Kimberly K Crouse, Lin Ji, Amy Brault, Kristen Ford, Jonathan Brooks, Scott A Jelinsky, Yizheng Li, Julia Shin, Yajuan Zhao, Christina Arnold, Richard Sheldon, Jon Volmer, Scott Bagley, Agustin Casimiro-Garcia, Gary Chinigo, Jennifer Davoren, Timothy Foley, Robert W. Hicklin, Shenping Liu, Nicole L Nedoma, Mihir Parikh, John Trujillo, Stefanus J. Steyn, Karl H. Nocka, Fabien VINCENT, Katherine Lee, Brian S. Gerstenberger, Michael J. Primiano, Tatyana Andreyeva, Katherine Hammerman, Jeonifer Garren, Wes LaBarge, Anthony Resek, Rajiah Aldrin Denny, Susan Drozda, Frank E. Lovering, Joseph W. Strohbach, Martin Hegen
| Nature Verified
Abstract Interleukin-2-inducible T cell kinase is expressed by T cells and amplifies T cell receptor-dependent signals. Interleukin-2-inducible T cell kinase deletion or inhibition reduces production of interleukin-4 and interleukin-13, key drivers of atopic dermatitis. Nerve growth factor signals via the receptor tropomyosin-related kinase A and may promote pruritus in atopic dermatitis lesions.
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