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Articles

Positive and negative aspects of mental health after unspecified living kidney donation: A cohort study

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By Emma Massey, Mathilde C. Pronk, Willij C. Zuidema, Willem Weimar
| Wiley Online Library Verified
Abstract Objectives Unspecified donors give a kidney to a stranger with end-stage kidney failure. There has been little research on the long-term impact of unspecified donation on mental health outcomes. The aim of this study was to assess the positive and negative aspects of mental health among unspecified donors. Design We invited all unspecified donors who donated a kidney between 2000 and 2016 at our centre to participate in an interview and to complete validated questionnaires.
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Down-Regulation of Surface CD28 under Belatacept Treatment: An Escape Mechanism for Antigen-Reactive T-Cells

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By Dennis A. Hesselink, Marjolein Dieterich, Rens Kraaijeveld, Willem Weimar, Carla C. Baan
| PLOS
The co-stimulatory inhibitor of the CD28-CD80/86-pathway, belatacept, allows calcineurin-inhibitor-free immunosuppression in kidney transplantation. However, aggressive T-cell mediated allogeneic responses have been observed in belatacept-treated patients, which could be explained by effector-memory T-cells that lack membrane expression of CD28, i.e. CD28-negative (CD28NULL) T-cells.
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