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William Cleveland

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Articles

Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production - Scientific Reports

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By Gaoxian Chen, Hunter Douglas, Zhu Li, William Cleveland, Demetris Yannopoulos, Ian Y. Chen, Claudius Balzer
| Nature Verified
Abstract Ischemia/reperfusion (I/R) injury significantly contributes to the morbidity and mortality associated with cardiac events. Poloxamer 188 (P188), a non-ionic triblock copolymer, has been proposed to mitigate I/R injury by stabilizing cell membranes. However, the underlying mechanisms remain incompletely understood, particularly concerning endothelial cell (EC) function and nitric oxide (NO) production.
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Cardioprotection by Poloxamer 188 is Mediated through Increased Endothelial Nitric Oxide Production

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By Gaoxian Chen, Hunter Douglas, Zhu Li, William Cleveland
| BioRxiv
Abstract Ischemia/reperfusion (I/R) injury significantly contributes to the morbidity and mortality associated with cardiac events. Poloxamer 188 (P188), a nonionic triblock copolymer, has been proposed to mitigate I/R injury by stabilizing cell membranes. However, the underlying mechanisms remain incompletely understood, particularly concerning endothelial cell function and nitric oxide (NO) production.
Open in Who Shared Issue with article?
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