William James Antonisamy

AMPA receptor Angelman syndrome cofilin hippocampal neurons PIEZO2 sensory neurons Significance Statement Angelman syndrome (AS) is a severe neurogenetic disorder characterized by significant motor and cognitive impairments; however, effective treatments remain elusive. Recent evidence implicates deficits in the mechanosensitive PIEZO2 channel and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor function, as well as cytoskeletal abnormalities in AS pathology.