William Matchett on Muck Rack

William Matchett

As seen in: Nature, Columns Magazine, Belfast Telegraph, The Irish News, Belfast News Letter, The Valdosta Daily Times, The Journal of Immunology, CapX, Quadrant Online
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Articles

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography - Nature Communications

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By Obinna C. Ubah, Jonathan S. Marchant, William Matchett, Joshua Thiede, Hideki Aihara, Caroline J. Barelle
| Nature Verified
Abstract Single-domain Variable New Antigen Receptors (VNARs) from the immune system of sharks are the smallest naturally occurring binding domains found in nature. Possessing flexible paratopes that can recognize protein motifs inaccessible to classical antibodies, VNARs have yet to be exploited for the development of SARS-CoV-2 therapeutics. Here, we detail the identification of a series of VNARs from a VNAR phage display library screened against the SARS-CoV-2 receptor binding domain (RBD).
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Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity

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By William Matchett, Vineet Joag, J. Michael Stolley, Frances K. Shepherd
| The Journal of Immunology Verified
Key Points Vaccine-elicited N-specific immunity confers protection against SARS-CoV-2. Memory CD8 T cells respond rapidly upon intranasal SARS-CoV-2 challenge. Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing Abs target the receptor binding domain of the spike (S) protein, a focus of successful vaccine efforts. Concerns have arisen that S-specific vaccine immunity may fail to neutralize emerging variants.
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Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity

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By William Matchett, Vineet Joag, J. Michael Stolley, Frances K. Shepherd
| The Journal of Immunology Verified
William E. Matchett, Vineet Joag, J. Michael Stolley, Frances K. Shepherd, Clare F. Quarnstrom, Clayton K. Mickelson, Sathi Wijeyesinghe, Andrew G. Soerens, Samuel Becker, Joshua M. Thiede, Eyob Weyu, Stephen D. O'Flanagan, Jennifer A. Walter, Michelle N. Vu, Vineet D. Menachery, Tyler D. Bold, Vaiva Vezys, Marc K. Jenkins, Ryan A.
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