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Winfried Barchet on Muck Rack

Winfried Barchet

As seen in: Color Research & Application, The Journal of Immunology
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Articles

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells

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By Chun-Feng Yu, Wen-Ming Peng, Martin Schlee, Winfried Barchet
| The Journal of Immunology Verified
SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells Chun-Feng Yu, Wen-Ming Peng, Martin Schlee, Winfried Barchet, Anna Maria Eis-Hübinger, Waldemar Kolanus, Matthias Geyer, Sebastian Schmitt, Folkert Steinhagen, Johannes Oldenburg, Natalija Novak The Journal of Immunology June 15, 2018, 200 (12) 4024-4035; DOI: 10.4049/jimmunol.1700510
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SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells

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By Winfried Barchet, Chun-Feng Yu, Wen-Ming Peng, Martin Schlee
| The Journal of Immunology Verified
SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells Chun-Feng Yu, Wen-Ming Peng, Martin Schlee, Winfried Barchet, Anna Maria Eis-Hübinger, Waldemar Kolanus, Matthias Geyer, Sebastian Schmitt, Folkert Steinhagen, Johannes Oldenburg, Natalija Novak The Journal of Immunology April 30, 2018, ji1700510; DOI: 10.4049/jimmunol.1700510
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Suppressive oligodeoxynucleotides containing TTAGGG motifs Inhibit cGAS activation in human monocytes

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By Thomas Zillinger, Winfried Barchet, Dennis M. Klinman, Eicke Latz, Folkert Steinhagen, Konrad Peukert, Mario Fox, Marcus Thudium, Christian Putensen, Christian Bode
| Color Research & Application Verified
Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi–Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN in response to cytosolic DNA and is potentially linked to SLE and AGS. Suppressive oligodeoxynucleotides (ODN) containing repetitive TTAGGG motifs present in mammalian telomeres have proven useful in the treatment of autoimmune diseases including SLE.
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