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Wini Zambare

As seen in: Nature, medRxiv
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Articles

Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma - Nature Communications

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By Paul B Romesser, Aron Bercz, Janet Alvarez, Caroline Kostrzewa, Elisa Liu, Yu-Jui Ho, Natasha Mohan, Marsha Reyngold, Rona Yaeger, John Cuaron, Jeanine Lisanti, Wini Zambare, Vasily N. Aushev, SHRUTI SHARMA, Meenakshi Malhotra, Samuel Rivero-Hinojosa, Nathan J. Schauer, Adham Jurdi, Minetta C. Liu, Abraham Noah Wu, Vonetta M. Williams, Louise Connell, Emmanouil Pappou, Devika Rao Verified, Neil H. Segal, Philip B. Paty, Martin Weiser, Andrea Cercek, Jorge E. Marcet, Julio Garcia-Aguilar, Chris Crane, Mithat Gonen, J. Joshua Smith, Angela Adames, Diana A. Roth O’Brien, Melissa Zinovoy, Christine Olinger, Revathi Ravella, Richard Tuli
| Nature Verified
Abstract Patients with anal squamous cell carcinoma (ASCC) who fail chemoradiation (CRT) have poor outcomes, underscoring the need for biomarkers to guide risk stratification. In a real-world two-center cohort of 84 adults with non-metastatic ASCC treated with curative-intent CRT, we prospectively evaluate a tumor-informed circulating tumor DNA (ctDNA) assay (SignateraTM, Natera).
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Integrating Tumor and Organoid DNA Methylation Profiles Reveals Robust Predictors of Chemotherapy Response in Rectal Cancer

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By Xi Chen, David Lukacsovich, Chao Wu, Wini Zambare
| medRxiv
J.J.S. received travel support for fellow education from Intuitive Surgical,and served as a clinical advisor for Guardant Health and Foundation Medicine, a consultant and speaker for Johnson and Johnson, and a clinical advisor and consultant for GlaskoSmithKline. The other authors have no conflicts ofinterest to declare. This research was supported by US National Cancer Institute grant R37CA248289 (J.J.S), and Sylvester Comprehensive Cancer Center Intramural program SCCC-NIH-2022-11 (X.S.C).
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