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Winka Le Clec'h on Muck Rack

Winka Le Clec'h

As seen in: BioRxiv
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Articles

Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni

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By Clair R. Henthorn, Paul McCusker, Winka Le Clec'h, Frédéric D Chevalier
| BioRxiv
Abstract There are limited control measures for the disease schistosomiasis, despite the fact that infection with parasitic blood flukes affects hundreds of millions of people worldwide. The current treatment, praziquantel, has been in use since the 1980's and there is a concern that drug resistance may emerge with continued monotherapy. Given the need for additional antischistosomal drugs, we have re-visited an old lead, meclonazepam.
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Contribution of parasite and host genotype to immunopathology of schistosome infections

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By Winka Le Clec'h, Frédéric D Chevalier, Timothy Anderson, Kathrin S. Jutzeler
| BioRxiv
Abstract Background: The role of pathogen genotype in determining disease severity and immunopathology has been studied intensively in microbial pathogens including bacteria, fungi, protozoa, and viruses, but is poorly understood in parasitic helminths. The medically important blood fluke Schistosoma mansoni is an excellent model system to study the impact of helminth genetic variation on immunopathology.
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A single locus determines praziquantel response in Schistosoma mansoni

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By Frédéric D Chevalier, Winka Le Clec'h, Matt Berriman, Tim Anderson
| BioRxiv
Abstract We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response.
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