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Wladimir Malaga on Muck Rack

Wladimir Malaga

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Articles

Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

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By Université de Toulouse, Université Toulouse III, Delphine Payros, Wladimir Malaga, PLOS Pathogens
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Loading metrics Open Access Peer-reviewed Research Article Abstract The molecular factors and genetic adaptations that contributed to the emergence of Mycobacterium tuberculosis (MTB) from an environmental Mycobacterium canettii-like ancestor, remain poorly investigated. In MTB, the PhoPR two-component regulatory system controls production and secretion of proteins and lipid virulence effectors. Here, we describe that several mutations, present in phoR of M.
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