Won Taek Lee on Muck Rack

Won Taek Lee

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Articles

TANK-binding kinase 1 protects against MASH progression via mitochondrial quality control

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By Sung-Min An, Jun Hee Jang, Jin Sung, Yong Geun Jeon, Won Taek Lee, Jin Jeon, Kyung Min Yim, Jae-Ho Lee, Bichen Zhang, Jong Bae Seo, Jae Bum Kim, Alan Saltiel, Ji Won Myung, Seung Soon Im
| Nature Verified
Abstract Mitochondrial dysfunction is a critical driver of metabolic dysfunction-associated steatotic liver disease progression to steatohepatitis (MASH), yet the mechanisms governing mitochondrial quality control in hepatocytes remain poorly defined. Here we identify TANK-binding kinase 1 (TBK1) as an essential regulator of hepatic mitophagy and lysosomal activity.
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Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates - Nature Communications

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By Yong Geun Jeon, Ji Seul Han, Won Taek Lee, Kyuri Jo, Je-Yoel Cho, Jiyoung Park, Sun Won Kim
| Nature Verified
Abstract In mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli. BAT rapidly generates heat through brown adipocyte activation, and further iWAT gradually stimulates beige fat cell differentiation upon prolonged cold challenges. However, fat depot-specific regulatory mechanisms for thermogenic activation of two fat depots are poorly understood.
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Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice - Nature Communications

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By Eun Seo Park, Yun Kyung Lee, Yong Geun Jeon, Jiyoung Park, Jong Kyoung Kim, Won Taek Lee
| Nature Verified
Abstract Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood. Here, we investigate transcriptional heterogeneity in adipose iNKT cells and their hierarchy using single-cell RNA sequencing in lean and obese mice.
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