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Wonkeon Koo

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Articles

Microglial protein kinase CK2 prevents obesity in mice potentially through NLRP3 inflammasome activation

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By Ji-Won Lee, Nayoun Kim, Seokjae Park, Hyeri Nam, Younghwan Lee, Seohyeon Hwang, Sehee Ha, Eun-Kyoung Kim, Seong-Woon Yu, Seolsong Kim, Yeim Lee, Wonkeon Koo
| Nature Verified
Abstract Protein kinase CK2 plays an important role in the regulation of metabolism and obesity. However, the metabolic role of CK2 and its substrates in the brain remain largely unknown. Here, we show that microglial CK2 is required for metabolic homeostasis through ASC phosphorylation and subsequent NLRP3 inflammasome–mediated interleukin (IL)−18 maturation and release.
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