Woo-Sup Sim

Abstract The regenerative function of stem cells is orchestrated by specialized niches, yet the mechanisms underlying mesenchymal stromal cell (MSC)–mediated support remain unclear. Here, we demonstrate that the epithelial-to-mesenchymal transition (EMT) gradient, together with stemness and pericyte-like properties, is a critical regulator of MSC niche function.

Abstract Neutrophils are critical mediators of both the initiation and resolution of inflammation after myocardial infarction (MI). Overexuberant neutrophil signaling after MI exacerbates cardiomyocyte apoptosis and cardiac remodeling while neutrophil apoptosis at the injury site promotes macrophage polarization toward a pro-resolving phenotype. Here, we describe a nanoparticle that provides spatiotemporal control over neutrophil fate to both stymie MI pathogenesis and promote healing.

Abstract Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of functionality. Therefore, in this study, we establish a perfusable culture system based on in vivo-like heart microenvironments to improve human cardiac tissue fabrication.