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Woochan Park

As seen in: Nature, MDPI
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Articles

Shared evolutionary trajectories underlying carcinogenesis and metastasis in biliary tract cancer

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By Minsu Kang, Ju Hyun Lee, Ji-Won Kim, Sejoon Lee, Kui-Jin Kim, Woochan Park, Jeongmin Seo, Heejung Chae, Eun Jung, Koung Jin Suh, Yejee Lim, Hyun Chang Kim, Jin Kim, Yu Jung Kim, Yoo-Seok Yoon, Jee Hyun Kim, Ho-Seong Han, Keun-Wook Lee, Songji Choi
| Nature Verified
Abstract The evolutionary dynamics of biliary tract cancer (BTC)—from precancerous transformation through metastatic dissemination and recurrence—remain poorly understood. We performed multi-regional and longitudinal whole-exome sequencing of 55 tumor specimens and 17 matched normals from 17 patients to reconstruct patient-specific phylogenetic trees and mutational signatures. TP53 (41.2%), KRAS (29.4%), and SMAD4 (23.5%) were the most frequently altered genes in primary tumors.
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Effect of Repeated Greater Occipital Nerve Block in Patients with Ocular Neuropathic Pain: A Retrospective Observational Study

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By Jonghwan Lee, Jinyoung Choi, Woochan Park, Geonho Lee
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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