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Woodring E. Wrighta

As seen in: American Society for Microbiology (ASM)
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Articles

Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation

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By Lu Zhang, Jimok Yoon, Nick V. Grishinc, Woodring E. Wrighta
| American Society for Microbiology (ASM)
Adenomatous polyposis coli (APC) is a key molecule to maintain cellular homeostasis in colonic epithelium by regulating cell-cell adhesion, cell polarity, and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (Asef). The APC-activated Asef stimulates the small GTPase, which leads to decreased cell-cell adherence and cell polarity, and enhanced cell migration.
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