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Wook Bum Pyun

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Articles

Aldosterone-renin ratio and plasma renin activity as biomarkers for treatment response in resistant hypertension

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By Kyeong-Hyeon Chun, Chan Joo Lee, Dong-Ho Shin, Jin-Ok Jeong, Ju Han Kim, JiWung Ryu, Hae-Young Lee, Seonghoon Choi, Eun Mi Lee, Jung Hyun Choi, Kwang-il Kim, Jinho Shin, Dae-Hee Kim, Bryan Williams, Sang-Hyun Ihm, Wook Bum Pyun
| Nature Verified
Abstract A recent randomised trial demonstrated the non-inferiority of amiloride versus spironolactone in resistant hypertension, with exploratory analyses suggesting heterogeneity in treatment response based on baseline aldosterone-renin ratio (ARR). We evaluated associations between baseline renin-aldosterone status and blood pressure-lowering responses to each agent. This post hoc subgroup analysis used data from the abovementioned trial.
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