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Wooping Ge

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Articles

Adenosine signalling drives antidepressant actions of ketamine and ECT - Nature

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By Zhaofa Wu, Yulong Li, Xiaohui Wang, Wooping Ge
| Nature Verified
Abstract Ketamine and electroconvulsive therapy (ECT) achieve rapid remission in treatment-resistant depression. However, their mechanisms of action—the understanding of which is essential for refining therapeutic precision—remain unclear1,2,3. Here, using mouse models, we identify adenosine signalling as a central pathway that underlies the antidepressant effects of these interventions.
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