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Woosuk Steve Hur on Muck Rack

Woosuk Steve Hur

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Articles

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD - Nature Communications

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By Xiaoqiong Wei, James Paton, Kezhong Zhang, Deyu Fang, Woosuk Steve Hur
| Nature Verified
Abstract Impaired secretion of an essential blood coagulation factor fibrinogen leads to hepatic fibrinogen storage disease (HFSD), characterized by the presence of fibrinogen-positive inclusion bodies and hypofibrinogenemia. However, the molecular mechanisms underlying the biogenesis of fibrinogen in the endoplasmic reticulum (ER) remain unexplored.
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