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Worcester Massachusetts

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Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2

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By Aniuska Becerra-Artiles, Molecular Biotechnology, Padma P. Nanaware, Worcester Massachusetts, PLOS Pathogens
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T-cell recognition of eluted HLA-DR and HLA-DP viral peptides We evaluated whether the naturally processed and presented viral peptides were recognized by circulating CD4 T cells in blood from healthy donors. We selected donors with a partial HLA match to HEK293 cells (donors expressing DRB1*15:01 and DRB5*01:01 for DR peptides, and donors expressing DPA1*01:03/DPB1*04:02 or DPB1*04:01 for DP peptides, S5 Table).
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